SI2006 Cardiac Systems Biology and Biomechanics

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  • Tuesday, Aug 8, Modeling myocyte excitation-contraction coupling and its regulation
    Instructors: Andrew McCulloch, Ph.D., Anushka Michailova, Ph.D., Sarah Flaim Ph.D., Stuart Campbell, Fred Lionetti
    Lecture notes on cardiac myocyte modeling ppt pdf
    Continuity Exercises
  • Wednesday, Aug 9, Finite element discretization and mesh fitting
    Instructors: Andrew McCulloch, Ph.D., Fred Lionetti
    Lecture notes on meshes and anatomic fitting ppt pdf
    Continuity Exercises
  • Thursday, Aug 10, Monodomain modeling in cardiac electrophysiolog
    Instructors: Sarah Flaim, Ph.D., Fred Lionetti, Andrew McCulloch, Ph.D.
    Lecture notes on monodomain modeling ppt pdf
    Continuity Exercises
  • Friday, Aug 11, Cardiac biomechanics and electromechanics modeling
    Instructors: Andrew McCulloch, Ph.D., Stuart Campbell, Fred Lionetti
    Lecture notes on biomechanics modeling ppt pdf
    Continuity Exercises

Suggested Reading

Introduction and background to cardiac modeling

McCulloch AD (2005) Cardiac Biomechanics. Chapter 54 in: The Biomedical Engineering Handbook, 3nd Edition, Volume I, Bronzino JD, Editor-in-Chief, CRC Press, Boca Raton, FL: pages 54-1 – 54-27.

Saucerman JJ, McCulloch AD (2004) Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation. Prog Biophys Molec Biol 2004;85(2/3):261-278.

Meshes and anatomic fitting

Vetter FJ, McCulloch AD (1998). Three-dimensional analysis of regional cardiac anatomy. Progress in Biophysics and Molecular Biology 69:157-183.

Mazhari R, Omens JH, Waldman LK, McCulloch AD (1998) Regional myocardial perfusion and mechanics: a model-based method of analysis. Ann Biomed Eng 1998;26:743-755.

Usyk TP, McCulloch AD (2003) Computational methods for soft tissue biomechanics. In Holzapfel GA, Ogden RW (Eds) Biomechanics of Soft Tissue in Cardiovascular Systems. Springer, Wien New York (CISM Courses and Lectures No. 441, International Center for Mechanical Sciences), pages 273-342.

Electrophysiology models Rudy R, Silva JR (2006) Computational biology in the study of cardiac ion channels and cell electrophysiology. Quarterly Reviews of Biophysics, pages 1-60.

Rogers JM, McCulloch AD (1994) A collocation-Galerkin finite element model of cardiac action potential propagation. IEEE Trans Biomed Eng 41:743-757.

Belik ME, Usyk TP, McCulloch AD (2004) Computational methods for cardiac electrophysiology. In (Ayache N, Guest Ed) Computational Models for the Human Body, Special Volume of (Ciarlet PG, Ed) Handbook of Numerical Analysis, Volume XII. Elsevier B.V., pages 129-188.

Biomechanics and electromechanics models

Costa KD, Hunter PJ, Rogers JM, Wayne JS, Guccione JM, Waldman LK, McCulloch AD (1996a,b) A three-dimensional finite element method for large elastic deformations of ventricular myocardium: Part I - Cylindrical and spherical polar coordinates and Part II - Prolate spheroidal coordinates. J Biomech Eng 118: 452-472.

Vetter FJ, McCulloch AD (2000) Three-dimensional stress and strain in passive rabbit left ventricle: A model study. Annals of Biomed Eng 28:781-792.

Kerckhoffs RCP, McCulloch AD (2005) Cardiac Electromechanics, In: Chien et al (Eds) (in press)

Kerckhoffs RCP, Healy SN, Usyk TP, McCulloch AD (2006) Computational methods for cardiac electromechanics. Proc IEEE 2006;94(4):769-783.

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