SI2006 Cardiac Systems Biology and Biomechanics
- Tuesday, Aug 8, Modeling myocyte excitation-contraction coupling and its regulation
- Wednesday, Aug 9, Finite element discretization and mesh fitting
- Thursday, Aug 10, Monodomain modeling in cardiac electrophysiolog
- Friday, Aug 11, Cardiac biomechanics and electromechanics modeling
Introduction and background to cardiac modeling
McCulloch AD (2005) Cardiac Biomechanics. Chapter 54 in: The Biomedical Engineering Handbook, 3nd Edition, Volume I, Bronzino JD, Editor-in-Chief, CRC Press, Boca Raton, FL: pages 54-1 – 54-27.
Saucerman JJ, McCulloch AD (2004) Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation. Prog Biophys Molec Biol 2004;85(2/3):261-278.
Meshes and anatomic fitting
Vetter FJ, McCulloch AD (1998). Three-dimensional analysis of regional cardiac anatomy. Progress in Biophysics and Molecular Biology 69:157-183.
Mazhari R, Omens JH, Waldman LK, McCulloch AD (1998) Regional myocardial perfusion and mechanics: a model-based method of analysis. Ann Biomed Eng 1998;26:743-755.
Usyk TP, McCulloch AD (2003) Computational methods for soft tissue biomechanics. In Holzapfel GA, Ogden RW (Eds) Biomechanics of Soft Tissue in Cardiovascular Systems. Springer, Wien New York (CISM Courses and Lectures No. 441, International Center for Mechanical Sciences), pages 273-342.
Electrophysiology models Rudy R, Silva JR (2006) Computational biology in the study of cardiac ion channels and cell electrophysiology. Quarterly Reviews of Biophysics, pages 1-60.
Rogers JM, McCulloch AD (1994) A collocation-Galerkin finite element model of cardiac action potential propagation. IEEE Trans Biomed Eng 41:743-757.
Belik ME, Usyk TP, McCulloch AD (2004) Computational methods for cardiac electrophysiology. In (Ayache N, Guest Ed) Computational Models for the Human Body, Special Volume of (Ciarlet PG, Ed) Handbook of Numerical Analysis, Volume XII. Elsevier B.V., pages 129-188.
Biomechanics and electromechanics models
Costa KD, Hunter PJ, Rogers JM, Wayne JS, Guccione JM, Waldman LK, McCulloch AD (1996a,b) A three-dimensional finite element method for large elastic deformations of ventricular myocardium: Part I - Cylindrical and spherical polar coordinates and Part II - Prolate spheroidal coordinates. J Biomech Eng 118: 452-472.
Vetter FJ, McCulloch AD (2000) Three-dimensional stress and strain in passive rabbit left ventricle: A model study. Annals of Biomed Eng 28:781-792.
Kerckhoffs RCP, McCulloch AD (2005) Cardiac Electromechanics, In: Chien et al (Eds) (in press)
Kerckhoffs RCP, Healy SN, Usyk TP, McCulloch AD (2006) Computational methods for cardiac electromechanics. Proc IEEE 2006;94(4):769-783.